3-chloro-4-(3-fluorobenzyloxy)aniline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine
Fluorinated Building Blocks
KUMI1F21
202197-26-0
MFCD06809822
253660461
9330964
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-chloro-4-(3-fluorobenzyloxy)aniline
C₁₃H₁₁ClFNO
251.69
≥98.0%
Pale yellow to Brown Solid
82-84ºC
5g,10g,50g,100g,500g,1kg and 25kg
Store at 2-8ºC(recommended)
3-Chloro-4-(3-fluorobenzyloxy)aniline is an intermediate in the synthesis of Lapatinib,which is a dual tyrosine kinase inhibitor which interrupts the HER2 /neu and epidermal growth factor receptor (EGFR) pathwaysan  and thus is used as an orally active drug for breast cancer and other solid tumours.
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series. [1]
Reference:
[1] K.G.Petrov, et al, Bioorg. Med. Chem. Lett., 2006, 16(17), pp4686-4691.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H341,H373,H410
P201,P202,P260,P264,P270,P273,P280,P301+P312+P330

UN 3077 9/PG III

1. Product Specification
2. Safety Data Sheet
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