3-fluorocyclobutan-1-ol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-fluorocyclobutanol
Fluorinated Building Blocks, F-labeling Fluorination
KUMI1F56
1380170-67-1
MFCD20482173
53963649

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3-fluorocyclobutan-1-ol
C4H7FO
90.10
≥95%
Colorless to Pale-yellow Liquid

1g,5g,10g,25g,50g and 100g
Store at room temperature
3-fluorocyclobutan-1-ol is a pharmaceutically useful fluorinated building block in the synthesis of pyrrolo{2,3-d}pyrimidine derivatives used as Janus Kinase (JAK) inhibitors. It also is employed as precursor in radiosynthesis of  the [18F] fluorocyclobutyl group, which is  potential to be a metabolically stable prosthetic group for PET tracers.
Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system. [1]
Reference:
[1] D. Franck, et al, Bioorg. Med. Chem., 2013, 21(3), pp 643-652.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P280,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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