3-Fluorophthalic anhydride 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Fluoro-2-benzofuran-1,3-dione
Fluorinated Building Blocks
KUMI1F150
652-39-1
MFCD00039696

Rea
69551

Reax
1283580
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Fluorophthalic anhydride 
C8H3FO3
166.11
95%
White to Pale yellow Solid
158-161°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
3-Fluorophthalic anhydride  (also named as 4-Fluoro-2-benzofuran-1,3-dione) is a useful fluorinated building block for the preparation of various compounds of interest in pharmaceutcials and agrochemicals.
New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor-α production inhibitors. [1]
Flubendiamide, a Novel Insecticide Highly Active against Lepidopterous Insect Pests. [2]
Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones. [3]
Sarcosine based indandione hGlyT1 inhibitors. [4]
1-Arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones as potent and selective α-1a/1d adrenergic receptor ligands. [5]
Antifungal activity of tautomycin and related compounds against Sclerotinia sclerotiorum. [6]
Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4). [7]
Development of the first small molecule histone deacetylase 6 (HDAC6) degraders. [8]
References:
[1] X.Collin, et al, Eur. J. Med. Chem., 2001, 36(7-8), pp 639-649.
[2] M.Tohnishi, et al, J. Pestic. Sci., 2005, 30(4), pp 354-360.
[3] M.Z.Huang, et al, J. Agric. Food Chem., 2005, 53(20), pp 7908-7914.
[4] C.G.Thomson, et al, Bioorg. Med. Chem. Lett., 2006, 16(5), pp 1388-1391.
[5] S.Li, et al, Bioorg. Med. Chem. Lett., 2007, 17(6), pp 1646-1650.
[6] X.Chen, et al, J. Antibiot. (Tokyo), 2011, 64(8), pp 563-569.
[7] K.E.Kil, et al, J. Med. Chem., 2014, 57(21), pp 9130-9138.
[8] K.Yang, et al, Bioorg. Med. Chem. Lett., 2018, 28(14), pp 2493-2497.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H317,H319,H335
P261,P280,P305+P351+P338
29173995900
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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