3-Fluoropyridine-2-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Fluoropicolinic acid
Fluorinated Building Blocks
KUMI1F156
152126-31-3
MFCD00040744

PubChem ID

PubChem ID

PubChem ID

PubChem ID
2762786

Reaxys ID
8050345
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Fluoropyridine-2-carboxylic acid 
C6H4FNO2
141.10
98%
White to Off-white Solid
152-155°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
3-Fluoropyridine-2-carboxylic acid  (also named as 3-Fluoropicolinic acid) is a fluorinated building block for the synthesis of various pharmaceuticals substances, such as specific carboxamides as KCNQ2/3 modulators, proteasome inhibitors, ghrelin receptor antagonists, etc..
Converting Core Compounds into Building Blocks: The Concept of Regiochemically Exhaustive Functionalization. [1]
In pursuit of natural product leads: Synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4- carboxylic acid (A-33853) and its analogues: Discovery of N-(2-benzoxazol-2- ylphenyl)benzamides as novel antileishmanial chemotypes. [2]
Structure-activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors. [3]
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists. [4]
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors. [5]
References:
[1] E.Marzi, et al, Eur. J. Org. Chem., 2005, 10, pp 2116-2123.
[2] S.K.Tipparajn, et al, J. Med. Chem., 2008, 51(23), pp 7344-7347.
[3] T.Watanabe, et al, Bioorg. Med. Chem. Lett., 2010, 20(19), pp 5839-5842.
[4] A.L.Blayo, et al, Bioorg. Med. Chem. Lett., 2015, 25(1), pp 20-24.
[5] Y.J. Wu, et al, Bioorg. Med. Chem. Lett., 2016, 26(23), pp 5729-5731.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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