4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
O-Desmorpholinopropyl Gefitinib
Fluorinated Building Blocks, [18]F-Labelled Precursors
KUMI1F19
184475-71-6


8928756
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
C₁₅H₁₁ClFN₃O₂
319.72
≥98.0%
Beige to Light brown Solid
285-288ºC
5g,10g,50g,100g,500g,1kg and 25kg
Store at room temperature,under inert atmosphere
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline(O-Desmorpholinopropyl Gefitinib) is a metabolite of Gefitinib, which is a potent inhibitor of tyrosine phosporylation in EGFR. Its another application is used to prepare a series of l F-18 labeled 4-aminoquinazoline derivatives for Potential PET imaging agents for tumor detection.
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. [1]
Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer. [2]
Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man. [3]
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: Potential PET imaging agents for tumor detection. [4]
References:
[1] M. Ranson, et al. J. Clin. Oncol., 2002, 20(9), PP2240-2250.
[2] J. Mendelsohn, J.Basega,J. Clin. Oncol.,2003, 21(4),pp2781-2799.
[3] D. Mckillop, et al, Xenobiotica, 2004, 34(10), pp917-934.
[4] Y. Chen, et al, Bioorg. Med. Chem. Lett., 2012, 22(14), pp4745-4749.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302
P264

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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