(4-chloro-2-fluoro-phenyl)-acetonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Chloro-2-fluorobenzyl cyanide, 2-(4-chloro-2-fluorophenyl)acetonitrile
Fluorinated Building Blocks
KUMI1F65
75279-53-7
MFCD01312758
2736569
3605106
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(4-chloro-2-fluoro-phenyl)-acetonitrile
C8H5ClFN
169.59
≥98%
Brown Solid
37-41°C
5g,10g,25g,50g,100g and 500g
Store at room temperature
(4-chloro-2-fluoro-phenyl)-acetonitrile is a useful fluorinated building block in the synthesis of various pharamceutical and API compounds, such as spironidolines as precursors of modulators of CCR2 receptor and p53-MDM2 inhibitor(RG7388).
An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC). [1]
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development. [2]
References:
[1] M.Behera, et al, Tetrahedron Lett., 2012, 53(9), pp 1060-1062.
[2] Q.Ding, et al, J. Med. Chem., 2013, 56(14), pp 5979-5983.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H311,H315,H319,H332,H335
P260,P280,P301+P310,P302+P352,P304+P340,P305+P351+P338

UN3439 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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