(4-chloro-2-fluoro-phenyl)-acetonitrile is a useful fluorinated building block in the synthesis of various pharamceutical and API compounds, such as spironidolines as precursors of modulators of CCR2 receptor and p53-MDM2 inhibitor(RG7388).
An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC). 
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development. 
 M.Behera, et al, Tetrahedron Lett., 2012, 53(9), pp 1060-1062.
 Q.Ding, et al, J. Med. Chem., 2013, 56(14), pp 5979-5983.