4-fluoro-2-methoxyaniline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-fluoro-2-methoxy-phenylamine
Fluorinated Building Blocks, Fluorinated API & Intermediates
KUMI1F69
450-91-9
MFCD00077536
13532228
3240531
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
4-fluoro-2-methoxyaniline
C7H8FNO
141.15
≥98.0%(GC)
Slightly pale yellow to Reddish yellow Clear Liquid
215°C
5g,10g,50g,100g,500g and1kg
Store at 2-8°C(recommended)
4-fluoro-2-methoxyaniline is a useful fluorinated intermediate in the preparation of various pharmaceutical substances, such as Mereletinib(AZD9291) as a third-generation epidermal growth factor receptor inhibitor,ortho-​substituted phenylureas as 5-​Hydroxytryptamine (5-​HT3) receptor antagonists ,hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.
5-Hydroxytryptamine (5-HT3) receptor antagonists. 2. 1-Indolinecarboxamides. [1]
Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain. [2]
A novel and efficient synthesis of anti-cancer agent, mereletinib. [3]
References:
[1] J.Bermudez, et al, J. Med. Chem., 1990, 33(7), pp 1929-1932.
[2] H.Seki, et al, Bioorg. Med. Chem., 2014, 22(3), pp 1208-1217.
[3] H.Liu, et al, J. Chem. Res., 2015, 39(6), pp 311-372.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P260,P280,P312
29214200
UN 2810 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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