4-(fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid is a trifunctional clickable probe building block for chemical probe synthesis,containing an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its formyl linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology synthesis.
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. 
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis. 
 J. Dong, L. Krasnova, M. G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed., 2014, 53(36), PP 9430-9448.
 O. Fadeyi, M. D. Parikh, M. Z. Chen, R. E. Kyne, A. P. Taylor, I. O'Doherty, S. E. Kaiser, S. Barbas, S. Niessen, M. Shi, S. L. Weinrich, J. C. Kath, L. H. Jones, R. P. Robinson, ChemBiochem, 2016, 17(20), pp 1925-1930.