5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN

Fluorinated Building Blocks
KUMI1F21
231278-84-5
MFCD10565688
253659811
9091685
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
C₂₆H₁₇ClFN₃O₃
473.89
≥98.0%
Dark brown Solid
224-229ºC
5g,10g,50g,100g,500g,1kg and 25kg
Store at room temperature
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde is an imtermediate in the synthesis of Lapatinib,which is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathwaysan  and therefore is used as an orally active drug for breast cancer and other solid tumours.
1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2. [1]
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. [2]
Epidermal growth factor receptor inhibitors: a new prospective in the treatment of lung cancer. [3]
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. [4]
References:
[1] I.K.Khanna, et al, J. Med. Chem., 1997, 40(11), pp1619-1633.
[2] L.N.Klapper,et al, Adv. Cancer. Res., 2000, 77, pp25-79.
[3] M.Tiseo, et al, Curr. Med. Chem. Anticancer Agents, 2004, 4(2), pp139-148.
[4] E.R. Wood, et al, Cancer Res., 2004, 64(18), pp6652-6659.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302
P264

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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