6-Fluoro-3-(piperidin-4-yl)-1,2-benzisoxazole hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
USP Paliperidone Related Compound, Risperidone EP Impurity M
Fluorinated Building Blocks
KUMI1F18
84163-13-3
MFCD06658529
253661962
5662739
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6-Fluoro-3-(piperidin-4-yl)-1,2-benzisoxazole hydrochloride
C12H13FN2O·HCl
256.71
≥98.0%(HPLC)(T)
White to Off-white Solid
>253ºC
5g,10g,50g,100g,500g,1kg and 25kg
Store at room temperature,under inert atmosphere
 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride is an important pharmaceutical intermediate for synthesis of Risperidone EP Impurity M and Paliperidone USP Related Compound B). Its thiourea and urea derivatives can be used as antimicrobial and Antioxidant agents representing a new calss of promising lead compounds.
Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure-activity relationship study. [1]
Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity. [2]
References:
[1] S.B. Benaka Prasad,K.Vinaya, C.S.Ananda Kumar, S.Sanjay, K.S.Rangappa,Invest New Drugs, 2009, 27(6), pp 534-542.
[2]  H.Sudhamani, S.K.T.Basha, N. Venkateswarlu, T.Vijaya, C.N.Raju, J. Chem. Sci., 2015, 127(10),pp 1739-1746.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P302+P352+P332+P313+P362+P364
2934.99.4400
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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