6-fluoro-3-hydroxypyrazine-2-carboxylic acid is a useful fluorinated building block and pharmaceutical intermediate in the synthesis of 6-fluoro-3- hydroxypyrazine-2-carboxamide commercially named favipiravir, which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza, acting on viral genetic copying to prevent its reproduction.
Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide. 
A practical and step-economic route to Favipiravir. 
 F.Shi, et al, Drug Discov. Ther., 2014, 8(3), pp 117-120.
 F.Lin, et al, Chem. Pap., 2017, 71(11), pp 2153-2158.