6-Fluoropyridine-3-carboxylic acid 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-Fluoronicotinic acid
Fluorinated Building Blocks, F-Labelling Precursors
KUMI1F160
403-45-2
MFCD01859863

PubChem ID

PubChem ID

PubChem ID

PubChem ID
242819
115990
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6-Fluoropyridine-3-carboxylic acid 
C6H4FNO2
141.10
98%
White to Off-white Solid
144-148°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
6-Fluoropyridine-3-carboxylic acid  (also named as 6-Fluoronicotinic acid) is a fluorinated building block for the synthesis of various pharmaceuticals substances and precursor for the radiosynthesis of PET melanoma imaging radiotracers.
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. [1]
Discovery of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. [2]
Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1. [3]
Pyridine carboxamides: Potent palm site inhibitors of HCV NS5B polymerase. [4]
Synthesis, structure determination, and (radio-)fluorination of novel functionalized phosphanes suitable for the traceless Staudinger ligation. [5]
Rapid radiosynthesis of two [18F]‐labeled nicotinamide derivatives for malignant melanoma imaging. [6]
References:
[1] X.Ouyang, et al, Bioorg. Med. Chem. Lett., 2006, 16(5), pp 1191-1196.
[2] I.Greguric, et al, J. Med. Chem., 2009, 52(17), pp 5299-5302.
[3] G.Rai, et al, J. Med. Chem., 2010, 53(20), pp 7392-7404.
[4] C.C.Cheng, et al, ACS Med. Chem. Lett., 2010, 1(9), pp 466-471.
[5] C.Mamat, et al, Tetrahedron, 2011, 67(25), pp 4521-4529.
[6] U.Seddik, et al, Appl. Radiat. Isot., 2018, 132, pp 142-146.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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