3,3-difluoro-1,2-diarylcyclopropenes (CpFluors) are a class of novel fluorination reagents with all-carbon scaffold(CCF reagents). They are crystalline, thermally stable, readily available, operationally simple and reactivity-tunable deoxyfluorinating reagents for the preparation of alkyl fluorides.
Their unique feature and potential application of this method are demonstrated in direct fluorination of monoalcohols through the cyclopropenium cation activation manner and acryloylative monofluorination of 1,2- and 1,3-diols through the cyclopropenone acetal activation manner.
In the selective and direct deoxyfluorination of multiple alcohos via nucleophilic fluorination, CpFluors are important complementary toolbox to other representative SF reagents( such as DAST, Deoxo-Fluor, XtalFluor-M, XtalFluor-E, Fluolead and PyFluor) and representative NCF reagents( such as Ishikawa reagent, DFMBA,TFFH and PhenoFluor).
Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes.
 L.Li, C. Ni, F. Wang, J. Hu, Nat. Commun.,2016, 7: 13320.