Ethyl 2-diethoxyphosphoryl-2-fluoroacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Fluoro-2-phosphonoacetic Acid Triethyl Ester
Fluorinating Reagents
KUMI1F200
2356-16-3
MFCD00134400

Rea
2734865

Reax
1912161
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Ethyl 2-diethoxyphosphoryl-2-fluoroacetate
C8H16FO5P
242.18
95%
Colorless to Pale yellow Liquid
190-200°C/16mmHg
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
Ethyl 2-diethoxyphosphoryl-2-fluoroacetate (also named as 2-Fluoro-2-phosphonoacetic Acid Triethyl Ester) is a fluorination reagent for the synthesis of fluorinated biochemical compounds with Horner reaction. It is also used as a fluorinated building block for the preparation of various pharmaceutical compounds of interest.
Fluorinated retinoic acids and their analogs. 3. Synthesis and biological activity of aromatic 6-fluoro analogs. [1]
7-Cis,9-cis,11-cis-Retinal, all cis-vitamin A and 7-cis,9-cis,11-cis-12-fluororetinal. New geometric isomers of vitamin A and carotenoids. [2]
Synthesis and gastrointestinal pharmacology of the 4-fluoro analog of enisoprost. [3]
2-Diethoxyphosphoryl alcanoic acid dianions (lithium α-lithiocarboxylates): IV. A direct route to 2-fluoro-2-alkenoic acids by the Horner synthesis. Application in the field of pyrethroids. [4]
Fluorinated analogs of aldehyde components of boll weevil pheromone. [5]
Acylation of fluorocarbethoxy-substituted ylides: a simple and general route to .alpha.-fluoro .beta.-keto esters. [6]
References:
[1] A.J.Lovery, et al, J. Med. Chem., 1982, 25(1), pp 71-75.
[2] A.E.Asato, et al, J. Am. Chem. Soc., 1983, 105(9), pp 2923-2924.
[3] P.W.Collins, et al, J. Med. Chem., 1987, 30(11), pp 1952-1955.
[4] Ph. Coutrot., et al, J. Organomet. Chem., 1987, 332,(1-2), pp 1-8.
[5] G.D.Prestwich, et al, J. Chem. Ecol., 1988, 14(15), pp 1427-1439.
[6] A.Thenappan, et al, J. Org. Chem., 1991, 56(1), pp 273-277.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2931399090
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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