Methyl 2-fluoroacrylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Methyl 2-fluoroprop-2-enoate, 2-Fluoroacrylic Acid Methyl Ester, MFA
Fluorinated Building Blocks
KUMI1F128
MFCD04039286
2343-89-7
2782524
1743169
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Boiling Point
Packaging
Storage
Methyl 2-fluoroacrylate
C4H5FO2
104.08
≥99%(GC)
Colorless Liquid
-42°C
95°C
5g,10g,25g,50g,100g,200g,500g and 1kg
Stabilized with BHT
Methyl 2-fluoroacrylate is a valuable fluorinated building block used for organic synthesis,Preparation of various pharmaceuticals and agrochemicals. Such as fluorinated analogues of naturally occurring 2,4-methanoproline and β-proline, more recently employed for the synthesis of polymer drugs, in which a polymer binding agent has a direct therapeutic effect on the body.
Asymmetric Diels–Alder reactions of 2-fluoroacrylic acid derivatives. Part 1: The construction of fluorine substituted chiral tertiary carbon. [1]
4-Fluoro-2,4-methanoproline. [2]
Synthesis of β-fluoro-β-proline. [3]
Polymers as drugs—Advances in therapeutic applications of polymer binding agents. [4]
References:
[1] H.Ito, et al, Tetrahedron: Asymmetry, 1998, 9(11), pp 1979-1987.
[2] A.N.Tkachenko, et al, Org. Lett., 2009, 11(24), pp 5674-5676.
[3] S.Vladimir, et al, Tetrahedron Lett., 2011, 52(12), pp 1300-1302.
[4] E.F.Connor, et al, J. Polym. Sci. Part A: Polym. Chem., 2017, 55(18), pp 3146-3157.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225,H314,H301,H330
P210,P280,P310
29161200
UN 3286 3(6.1+8)/PG II

1. Product Specification
2. Safety Data Sheet
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