Methyl 3-Fluoro-2-thiophenecarboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-fluoro-2-carbomethoxythiophene,Methyl 3-fluorothiophene-2-carboxylate
Fluorinated Building Blocks, F-Labeling Precursors
KUMI1F59
100421-52-1
MFCD16606491
10583081
6386122
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 3-Fluoro-2-thiophenecarboxylate
C6H5FO2S
160.17
≥98%(GC)
White to Yellow Solid
48-50°C
1g,5g,10g,25g and 50g
Store at room temperature
Methyl 3-Fluoro-2-thiophenecarboxylate is a useful fluorinated building block in the synthesis of various pharmaceutically active compounds. It is also employed as a radiofluorinating precursor to prepare [18F]fluoroarenes and [18F]-labeled neuropeptide.
Attempted syntheses of aminofluorothiophenes. [1]
Ring fluorinated thiophenes: Applications to liquid crystal synthesis. [2]
A facile and improved synthesis of 3-fluorothiophene. [3]
Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones. [4]
References:
[1] F.Kobarfard, et al, J. Heterocyclic Chem., 1999, 36(5), pp 1247-1251.
[2] A.A.Kiryanov, et al, Tetrahedron Lett., 2001, 42(50), pp 8797-8800.
[3] M.Pomerantz, et al, Synthesis, 2008, 15, pp 2333-2336.
[4] M.K. Narayanam, et al, Angew. Chem. Int. Ed, 2017, 56(42), pp 13006-13010.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods



NONH for all modes of transport

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