1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
Phenofluor™
Fluorinating Reagents
KUMI2F13
1314657-40-3
MFCD022377831
329768478
21745897
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole
C27H36F2N2
426.59
98%
White to Off-white Solid
213°C
5g,10g,25g,50g,100g,250g and 500g
Stored 2-8°C (Prepared into 0.1M solution in Toulene avoiding deliquescence when transport and storage)
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole(also known as Phenofluor™) is a new nucleophilic deoxyfluorinating reagent that delivers aryl fluorides from phenols in a one-step, high–yield, ipso substitution reaction. It's air stable and can be stored in anhydrous toluene for about two months without detectable decomposition. The method is operationally simple, regiospecific, scalable, and compatible with a variety of functional groups including amines, aldehydes, and heterocycles. More recently, it was reported that PhenoFluor™ can be used in a Late Stage Functionalization (LSF) strategy by deoxyfluorinating several natural products and drug-like molecules in a highly regioselective fashion.
Deoxyfluorination of phenols. [1]
Late-stage deoxyfluorination of alcohols with PhenoFluor. [2]
PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics. [3]
References:
[1] P.Tang, et al, J. Am. Chem. Soc., 2011, 133, pp 11482-11484.
[2] F.Sladojevich, et al, J. Am. Chem. Soc., 2013, 135, pp 2470–2473.
[3] T.Fujimoto, et al, Org. Proc. Res. Develop., 2014, 18, pp 1041-1044.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225,H304,H315,H336,H361,H373
P210,P261,P281,P301+P310,P331
3824999299
UN 1294 3/PG II
Phenofluor is a registered trademark of SciFluor Life Sciences, LLC
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