Stored 2-8°C (Prepared into 0.1M solution in Toulene avoiding deliquescence when transport and storage)
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole(also known as Phenofluor™) is a new nucleophilic deoxyfluorinating reagent that delivers aryl fluorides from phenols in a one-step, high–yield, ipso substitution reaction. It's air stable and can be stored in anhydrous toluene for about two months without detectable decomposition. The method is operationally simple, regiospecific, scalable, and compatible with a variety of functional groups including amines, aldehydes, and heterocycles. More recently, it was reported that PhenoFluor™ can be used in a Late Stage Functionalization (LSF) strategy by deoxyfluorinating several natural products and drug-like molecules in a highly regioselective fashion.