Pyridine hydrofluoride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
HF-Pyridine, Pyridinium polybifluoride, Olah′s reagent, PPHF
Fluorinlating Reagents
KUMI1F117
62778-11-4
MFCD00012436
64774

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(HF)
Appearance
Boiling Point
Packaging
Storage
Pyridine hydrofluoride
C5H6NF
99.11
≥70%
Colorless to Pale yellow Liquid
50°C/1 mmHg(lit.)
5g,10g,25g,50gl,100g,500g,1kg,5kg and 25kg
Store at room temperature
Pyridine hydrofluoride (also named as Olah′s reagent, PPHF) is a convenient reagent for organic fluorination reactions, e.g. employed with selectfluor for the geminal fluorination of 2,2-diaryl-1,3-dithiolanes. It is also used as reactant for the preparation of various target compounds, such as Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction; Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure; Candidates for nucleic acid drugs, ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorination, etc..
Synthetic methods and reactions. 63. Pyridinium poly(hydrogen fluoride) (30% pyridine-70% hydrogen fluoride): a convenient reagent for organic fluorination reactions. [1]
Synthetic Methods and Reactions. Part 106. Suppression of anchimerically assisted rearrangement products in the synthesis of α‐fluorocarboxylic acids from α‐amino acids with 48:52 (w/w) hydrogen fluoride/pyridine. [2]
The synthesis of glycosyl fluorides using pyridinium poly(hydrogen fluoride). [3]
The synthesis of glycosyl fluorides. [4]
gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor and pyridinium polyhydrogen fluoride. [5]
References:
[1] G.A.Olah, et al, J. Org. Chem., 1979, 44(22), pp 3872-3881.
[2] G.A.Olah, et al, Helvetica, 1981, 64(8), pp 2528-2530.
[3] A.W.Szarek, et al, Chem. Lett., 1984, 13(10), pp 1751-1754.
[4] M.Hayashi, et al, Chem. Lett., 1984, 13(10), pp 1747-1750.
[5] V.P.Reddy, et al, Chem. Commun., 2005, 7(5), pp 654-656.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314,H300+H310+H330
P361+P353,P304+P340+P310,P305+P351+P338
2933310000
UN 1790 8(6.1)/PG I

1. Product Specification
2. Safety Data Sheet
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