Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester
Fluorinated Building Blocks
KUMI1F198
211108-50-8
MFCD10566554

Reax
10560711

Reax
8257064
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate
C10H16FNO3
217.24
95%
White to Brown Solid
73-78°C
5g,10g,25g,50g,100g,250g and 500g
Store at room temperature
Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (also named as 1-Boc-3-fluoro-4-oxopiperidine) is a fluorinated building block for the synthesis of various pharmaceuticals and radiopharmaceuticals, such as 5-HT receptor agonists, NPY-1 antagonists, Janus kinase 1 inhibitors and PET radiotracer for the NR2B subtype N-methyl-d-aspartate receptor.
Synthesis and in vitro biological evaluation of fluoro-substituted-4- phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates. [1]
Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists. [2]
Synthesis and in vitro characterization of trans- and cis-[ 18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3- fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor. [3]
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. [4]
Discovery of a novel class of imidazo[1,2-a ]pyridines with potent PDGFR activity and oral bioavailability. [5]
References:
[1] A.B.Beeler, et al, Bioorg. Med. Chem., 2003, 11(23), pp 5229-5234.
[2] R.Di Fabio, et al, Bioorg. Med. Chem. Lett., 2006, 16(6), pp 1749-1752.
[3] R.Koudih, et al, Eur. J. Med. Chem., 2012, 53, pp 408-415.
[4] C.A.Hurley, et al, Bioorg. Med. Chem. Lett., 2013, 23(12), pp 3592-3598.
[5] E.J.Hichen, et al, ACS Med. Chem. Lett., 2013, 5(1), pp 78-83.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H319
P305+P351+P338
2933399990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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