Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (also named as 1-Boc-3-fluoro-4-oxopiperidine) is a fluorinated building block for the synthesis of various pharmaceuticals and radiopharmaceuticals, such as 5-HT receptor agonists, NPY-1 antagonists, Janus kinase 1 inhibitors and PET radiotracer for the NR2B subtype N-methyl-d-aspartate receptor.
Synthesis and in vitro biological evaluation of fluoro-substituted-4- phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates. 
Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists. 
Synthesis and in vitro characterization of trans- and cis-[ 18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3- fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor. 
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. 
Discovery of a novel class of imidazo[1,2-a ]pyridines with potent PDGFR activity and oral bioavailability.