(trans)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1R,2R)-2-fluorocyclopropan-1-amine;4-methylbenzenesulfonic acid
Fluorinated Building Blocks
KUMI1F184
1799439-05-6
MFCD28902517

PubChem ID

PubChem ID

PubChem ID

PubChem ID

PubChem ID

PubChem ID
91758946

Reaxys ID

Reaxys ID

Reaxys ID
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(trans)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate
C10H14FNO3S
247.28
95%
White to Pale yellow Solid
178-179°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
(trans)-2-fluorocyclopropanamine 4-methylbenzenesulfonate is a racemic monofluorinated three-member ring buidling block for the synthesis of Sitafloxacin (also called DU-6859), which is fluoroquinolone antibiotic that show promise in the treatment of buruli ulcer.
Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution. [1]
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. [2]
Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety. [3]
References:
[1] O.Tamura, et al, Tetrahedron, et al, 1994, 50(13), pp 3889-3904.
[2] R.Miyauchi, et al, Bioorg. Med. Chem., 2009, 17(19), pp 6879-6889.
[3] H.Liu, et al, Eur. J. Med. Chem., 2014, 86, pp 628-638.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P271,P280
2921309990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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