The introduction of fluorine moieties into organic molecules can significantly alter their chemical, physical and pharmacological properties, and fluorination has become a routine and powerful strategy in the design of new material and drug candidates due to the fluorine atom's electronnegativity and small size.In pharmaceutical research, fluorine additions to target compounds are proved to enhhance their bioavailability, stability and lipophilicity. Approximately 20% of pharmaceuticals and 30% of agrochemicals on the market contain fluorine. HMG-CoA reductase inhibitor fluorostatin(atorvastatin), antibiotic fluoroquinolone(levofloxacin), and antitumor fluoronucleoside(tegafur) are successful examples of the incorporation of fluorine into organic molecules.
Since natural sources of fluoroorganic compounds are extremely rare, it is necessary to fluorinate organic compounds at a certain stage of the syntheses. Further more, yet still today, the efficient fluorination of functionalized compounds remains significant challenges.
We are pleased to offer continually-expanding Product catalogue of fluorinating reagents and building blocks to make fluorination easier.
The chart on the right demonstrates the basic common strategy employed for fluorination and highlights some key reagents that we are featuring for our customers.
Our Fluorinating Reagents and Building Blocks are divided into the following Product Groups:
(Click each block for more information on individual product group)
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