1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid
Difluoromethylated Building Blocks
KUMI2F251
862574-88-7
MFCD13190001
44206103
11430158
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
C11H8F2O4
242.18
≥98%
White to Yellow Solid

5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid is a difluorinated intermediate that typically used in the preparation of VX-770 and VX-809 as potent CFTR correctors for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation.
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. [1]
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. [2]
References:
[1] F.Van Goor, et al, Proc. Natl. Acad. Sci. USA, 2011, 108(46), pp 18843-18848.
[2] J.E.Doiron, et al, Chemistry, 2019, 25(14), pp 3662-3674.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P280,P305+P351+P338
2932990025
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.