1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid is a difluorinated intermediate that typically used in the preparation of VX-770 and VX-809 as potent CFTR correctors for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation.
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. 
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. 
 F.Van Goor, et al, Proc. Natl. Acad. Sci. USA, 2011, 108(46), pp 18843-18848.
 J.E.Doiron, et al, Chemistry, 2019, 25(14), pp 3662-3674.
NONH for all modes of transport
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