(4R)-4-(Difluoromethyl)-2,2-dimethyl-1,3-dioxolane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(R)-4-(Difluoromethyl)-2,2-dimethyl-1,3-dioxolane
Difluoromethylated Building Blocks
KUMI2F252
925422-86-2
 
10953703
9321651
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
(4R)-4-(Difluoromethyl)-2,2-dimethyl-1,3-dioxolane
C6H10F2O2
152.14
≥98%
Colorless to Pale Yellow Liquid

5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
(4R)-4-(Difluoromethyl)-2,2-dimethyl-1,3-dioxolane is a difluorinated intermediate that typically used in the preparation of GDC-0077 as a potent and selective PI3K inhibitor with potential antineoplastic activity for the treatment of breast cancer.
GDC-0077 is a selective PI3K alpha inhibitor that demonstrates robust efficacy in PIK3CAmutant breast cancer models as a single agent and in combination with standard of care therapies. [1]
Reference:
[1] R.Hong, et al, Cancer Res., 2018, 78(4), .
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225
P210
2932990090
UN 1993 3/PG II

1. Product Specification
2. Safety Data Sheet
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