Fluoromethyl 4-methylbenzenesulfonate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Fluoromethyl tosylate, FMTS
Fluoromethylating Reagents, [18F]F-Labeled Radioligands
KUMI1F199
114435-86-8
MFCD20482732
13862289
9477915
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Fluoromethyl 4-methylbenzenesulfonate
C8H9FO3S
204.22
≥98%(GC)
Colorless to Pale yellow Liquid
 
5g,10g,25g,50g,100g and 500g
Store at room temperature
 Fluoromethyl 4-methylbenzenesulfonate is typically used for the preparation of [18F] F-Labeled Radioligands in the application of PET Imaging agents. It is also empolyed as an electrophilic monofluoromethylating reagent in organic synthesis.
Radiosynthesis of O-[11C]methyl-L-tyrosine and O-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport. [1]
Improved synthesis of [18F]fluoromethyl tosylate, a convenient reagent for radiofluoromethylations. [2]
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging. [3]
Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent. [4]
Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity. [5]
Automated synthesis and purification of [18F]fluoro-[di-deutero] methyl tosylate. [6]
Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor. [7]
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. [8]
Identification and in vivo evaluation of a fluorine-18 rolipram analogue, [18F]MNI-617, as a radioligand for PDE4 imaging in mammalian brain. [9]
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography. [10]
Monofluoromethyl-Substituted Sulfonium Ylides: Electrophilic Monofluoromethylating Reagents with Broad Substrate Scopes. [11]
References:
[1] R.Iwata, et al, J. Label. Compd. Radiopharm., 2003, 46(6), pp 555-566.
[2] T.R.Neal, et al, J. Label. Compd. Radiopharm., 2005, 48(8), pp 557-568.
[3] S.R.Donohue, et al, J. Med. Chem., 2008, 51(18), pp 5833-5842.
[4] U.Berndt, et al, J. Label. Compd. Radiopharm., 2008, 51(3), pp 137-145.
[5] H.Fan, et al, Eur. J. Med. Chem., 2009, 44(2), pp 593-608.
[6] F.Beyerlein, et al, J. Label. Compd. Radiopharm., 2013, 56(7), pp 360-363.
[7] L.Hortala, et al, Bioorg. Med. Chem. Lett., 2014, 24(1), pp 283-287.
[8] Z.Zhang, et al, Bioorg. Med. Chem. Lett., 2015, 25(18), pp 3956-3960.
[9] D.Thomae, et al, J. Label. Compd. Radiopharm., 2016, 59(5), pp 205-213.
[10] M.Cantore, et al, ChemMedChem., 2016, 11(1), pp 108-118.
[11] Y.Liu, et al, Angew. Chem. Int. Ed. Engl., 2017, 56(33), pp 9930-9934.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H314,H317
P310,P260,280,P305+P351+P338
29051100
UN3265 8/PG II

1. Product Specification
2. Safety Data Sheet
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