1-azido-3-(bromomethyl)-5-ethynylbenzene

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Bromo arylzaide alkyne
Non-Fluorochemicals, Probe Building Blocks
KUMI0F19
849607-22-3


9903227
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-azido-3-(bromomethyl)-5-ethynylbenzene
C9H6BrN3
236.07
≥95.0%(NMR)
Solid

250mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
1-azido-3-(bromomethyl)-5-ethynylbenzene is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated arylazide (photoreactive group), terminal alkyne tag (clickable handle), and bromine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its brominated linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle. [1]
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [2]
Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. [3]
References:
[1] T.Hosoa, T.Hiramatsu, T.Ikemoto, H.Aoyama, T.Ohmae, M.Endo,M.Suzuki, Bioorg. Med. Chem. Lett., 2005, 15(5), pp 1289-1294.
[2] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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