1-hydroxyhept-6-yn-3-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-oxidanylhept-6-yn-3-one
Non-Fluorochemicals
KUMI0F22
1450754-40-1
MFCD29041964
101043814
23901051
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
1-hydroxyhept-6-yn-3-one
C7H10O2
126.16
≥95.0%
Colorless to Pale-yellow Liquid

1g,5g,10g,25g,50g and 100g
Store at 2-8 °C temperature
1-hydroxyhept-6-yn-3-one is a biologically useful precursor for prepartion of photo-reactive and "clickable" affinity-based probes (AfBPs), e.g.  synthesis of multifunctional terminal alkyne-containing diazirine photo-crosslinglinkers.
Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling. [1]
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors. [2]
Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. [3]
A Whole Proteome Inventory of Background Photocrosslinker Binding. [4]
Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker. [5]
References:
[1] Z.Li, et al, Angew. Chem. Int. Ed., 2013, 52(33), pp 8551-8556.
[2] B.Zhu, et al, Chemistry, 2016, 22(23), PP 7824-7836.
[3] Y.Xie, et al, J. Am. Chem. Soc., 2016, 135(48), pp 15596-15604.
[4] P.Kleiner,et al, Angew. Chem. Int. Ed., 2017, 56(5), pp 1396-1401.
[5] D.He, et al, Angew. Chem. Int. Ed., 2017, 56(46), pp 14521-14525.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P280,P305+P351+P338

NONH for all modes of transport

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