1-hydroxyhept-6-yn-3-one is a biologically useful precursor for prepartion of photo-reactive and "clickable" affinity-based probes (AfBPs), e.g. synthesis of multifunctional terminal alkyne-containing diazirine photo-crosslinglinkers.
Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling.
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors.
Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. 
A Whole Proteome Inventory of Background Photocrosslinker Binding. 
Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker.