2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine
Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-(but-3-ynyl)-3-(2-aminoethyl)-3H-diazirine, Amino diazirine alkyne
Non-Fluorochemicals, Probe Building Blocks
KUMI0F17
1450752-97-2
MFCD29918288
118987358
23901063
-3H-diazirin-3-yl)ethan-1-amine_product.png)
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine
C7H11N3
137.18
≥97.0%(NMR)
Colorless to Pale Yellow Liquid
192.5°C
100mg,200mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemical biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and amine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its amine linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [1]
Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. [2]
“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling. [3]
Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid. [4]
A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus. [5]
References:
[1] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
[2] Z.Li, et al, Angew. Chem. Int. Ed. Engl., 2013, 52(33), pp 8551-8556.
[3] Z.Li, et al, J. Am. Chem. Soc., 2014, 136(28), pp 9990-9998.
[4] H.Guo, et al, Chem. Commun.(Camb.), 2017, 53(69), pp 9620-9623.
[5] C.Fetzer, et al, Angew. Chem. Int. Ed. Engl., 2017, 56(49), pp 15746-15750.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture
2933.99.8090
NONH for all modes of transport
1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.