3-(2-hydroxyethyl)-3-methyl-3H-diazirine is a pharmaceutically useful intermediate in the synthesis of Itraconazole analogues for inhibition of endothelial cell proliferation, displaying antiangiogenic and antihedgehog activity and in the synthesis of anticonvulsant methoxypropionamides. It is also employed as building block for preparing photoreactive compounds, e.g. diubiquitin-based photoaffinity probes.
diazirine-containing building blocks
The structure-activity relationship of the 3-Oxy site in the anticonvulsant (R)- N -benzyl 2-acetamido-3-methoxypropionamide.
Photoaffinity-labeled peptoids and depsipeptides by multicomponent reactions. 
Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. 
Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins. 
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