3-(2-hydroxyethyl)-3-methyl-3H-diazirine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Hydroxy-2-(3-methyl-3H-diaziren-3-yl)ethane
Non-Fluorochemicals,Probe Building Blocks
KUMI0F42
25055-82-7
MFCD22683730
14859129
742003
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3-(2-hydroxyethyl)-3-methyl-3H-diazirine
C4H8N2O
100.12
≥97.0%(NMR)
Colorless to Yellow Liquid
194.6°C
100mg,200mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
3-(2-hydroxyethyl)-3-methyl-3H-diazirine is a pharmaceutically useful intermediate  in the synthesis of Itraconazole analogues for inhibition of endothelial cell proliferation, displaying antiangiogenic and antihedgehog activity and in the synthesis of anticonvulsant methoxypropionamides. It is also employed as building block for preparing photoreactive compounds, e.g. diubiquitin-based photoaffinity probes.
diazirine-containing building blocks
The structure-activity relationship of the 3-Oxy site in the anticonvulsant (R)- N -benzyl 2-acetamido-3-methoxypropionamide. [1]
Photoaffinity-labeled peptoids and depsipeptides by multicomponent reactions. [2]
Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. [3]
Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins. [4]
References:
[1] P.Morieux, et al, J. Med. Chem., 2010, 53(15), pp 5716-5726.
[2] M.Henze, et al, Synthesis, 2010, 17, pp 2997-3003.
[3] W.Shi, et al, J. Med. Chem., 2011, 54(20), pp 7363-7374.
[4] J.Liang, et al, Angew. Chem. Int. Ed. Engl., 2017, 56(10), pp 2744-2748.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P260,P280,P312
2922.19.8000
NONH for all modes of transport

1. Product Specification
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