3-(3-methyl-3H-diazirine-3-yl)propionic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Methyl-diazirine-3-propanoic Acid,4,4-azo-pentanoic acid
Non-Fluorochemicals,Probe Building Blocks
KUMI0F43
25055-86-1
MFCD19228230
14248197
742553
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3-(3-methyl-3H-diazirine-3-yl)propionic acid
C5H8N2O2
128.13
≥97.0%(NMR)
Pale yellow to Brown Liquid
278.5°C
100mg,200mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
3-(3-methyl-3H-diazirine-3-yl)propionic acid is a useful  cross-linking building block in the synthesis of diazirine-based multifunctional photoaffinity probes with numerous potential applications in functional proteomics of biomolecular interactions.
Photoactivatable Crosslinking Sugars for Capturing Glycoprotein Interactions. [1]
Total Synthesis of Photoactivatable or Fluorescent Anandamide Probes: Novel Bioactive Compounds with Angiogenic Activity. [2]
Photoaffinity-labeled peptoids and depsipeptides by multicomponent reactions. [3]
Diazirine-Containing Photoactivatable Isoprenoid: Synthesis and Application in Studies with Isoprenylcysteine Carboxyl Methyltransferase. [4]
A diazirine-based photoaffinity probe for facile and efficient aptamer–protein covalent conjugation. [5]
Simple Light-Triggered Fluorescent Labeling of Silica Nanoparticles for Cellular Imaging Applications. [6]
RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome. [7]
References:
[1] Y.Tanaka, J. Am. Chem. Soc., 2008, 130(11), pp 3278-3279.
[2] L.Balas, et al, J. Med. Chem., 2009, 52(4), pp 1005-1017.
[3] P.Morieux, et al, J. Med. Chem., 2010, 53(15), pp 5716-5726.
[4] J.S.Vervacke, et al, J. Org. Chem., 2014, 79(15), pp 1971-1978.
[5] H.Zhang, et al, Chem. Commun., 2014, 50(38), pp 4891-4894.
[6] R.Sun, et al, Chem. Eur. J., 2017, 23(56), pp 13893-13896.
[7] A.E.Argnello, J. Am. Chem. Soc., 2017, 139(48), pp 17249-17252.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P260,P280,P312
2922.19.8000
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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