3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Iodo diazirine alkyne
Non-Fluorochemicals, Probe Building Blocks
KUMI0F18
1450754-38-7
MFCD29918289
118987359
23901061
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine
C7H9IN2
248.06
≥97.0%(NMR)
Colorless Liquid

250mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and iodine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its iodinated linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [1]
Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. [2]
“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling. [3]
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors. [4]
Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. [5]
References:
[1] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
[2] Z.Li, P.Hao, L.Li, C.Y.J.Tan, X. Cheng, G.Y.J.Chen, S.K.Sze, H.M.Shen, S.Q.Yao, Angew. Chem. Int. Ed. Engl., 2013, 52(33), pp 8551-8556.
[3] Z.Li, D.Wang, L.Li, S.Pan, Z.Na, C.Y.J.Tan, S.Q.Yao, J. Am. Chem. Soc., 2014, 136(28), pp 9990-9998.
[4] B.Zhu, H.Zhang, S.Pan, C.Wang, J.Ge, J.S.Lee, S.Q.Yao, Chem. Eur. J., 2016, 22(23), pp 7824-7836.
[5] Y.Xie,J.Ge,H.Lei,B.Pang,H.Zhang,D.Wang,S.Pan,G.Chen,L.Chen,Y.Wang,Q.Hao,S.Q.Yao,H.Sun, J. Am. Chem. Soc., 2016, 138, pp 15596-15604.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture



NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.