3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and iodine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its iodinated linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry.
Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. 
“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling. 
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors. 
Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases.