3-oxocyclobutane-1-carbonitrlle

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-oxidanylidenecyclobutane-1-carbonitrile, 3-ketocyclobutanecarbonitrile
Non-Fluorochemicals
KUMI0F50
20249-16-5
MFCD01087798
13082390
2715659
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-oxocyclobutane-1-carbonitrlle
C5H5NO
95.10
≥97%(GC)
White to Yellow Solid
49-51°C
5g,10g,20g,50g,100g and 500g
Store at room temperature
3-oxocyclobutane-1-carbonitrlle is a useful building block for the synthesis of various pharmaceutical compounds, e.g. substituted hydroxyethyl amine compounds as beta-secretase modulators and azetinine and cyclobutane derivatives as JAK inhibitors, etc..
The exhaustive silylation of 5-nitro-pentan-2-one: Novel processes and opportunities. [1]
A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid. [2]
Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B. [3]
Synthesis of novel 2-azabicyclo[3.1.1]heptane-5-carboxylic acid. [4]
Highly Diastereoselective α-Arylation of Cyclic Nitriles. [5]
References:
[1] A.A.Tishkov, et al, Tetrahedron, 2001, 57(11), pp 2221-2230.
[2] D.Elend, et al, Synth. Commun., 2005, 35(5), pp 657-662.
[3] X.Zhang, et al, Bioorg. Med. Chem. Lett., 2013, 23(13), pp 3947-3953.
[4] S.He, et al, Tetrahedron Lett., 2016, 57(11), pp 1268-1269.
[5] M.E.Dalziel, et al, Org. Lett., 2017, 19(13), pp 3446-3449.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H332,H335
P264,P302+P352,P304+P340,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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