3-oxocyclobutane-1-carbonitrlle is a useful building block for the synthesis of various pharmaceutical compounds, e.g. substituted hydroxyethyl amine compounds as beta-secretase modulators and azetinine and cyclobutane derivatives as JAK inhibitors, etc..
The exhaustive silylation of 5-nitro-pentan-2-one: Novel processes and opportunities.
A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid.
Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B. 
Synthesis of novel 2-azabicyclo[3.1.1]heptane-5-carboxylic acid.
Highly Diastereoselective α-Arylation of Cyclic Nitriles. 
 A.A.Tishkov, et al, Tetrahedron, 2001, 57(11), pp 2221-2230.
 D.Elend, et al, Synth. Commun., 2005, 35(5), pp 657-662.