(4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and amine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its PEGylated amine linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry.
Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment.
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.