4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Carboxyl benzophenone alkyne
Non-Fluorochemicals, Probe Building Blocks
KUMI0F12
1236196-77-2
MFCD21648478
53341689
21164276
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid
C17H12O4
280.27
≥95.0%(HPLC)
Off-white to White Solid
197-202°C
250mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and carboxylic acid synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its acid linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. [1]
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [2]
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. [3]
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. [4]
References:
[1] M.Van Scherpenzeel, et al, Chembiochem, 2009, 10(10), pp 1724-1733.
[2] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
[3] H. Xu, et al, Mol. Biosyst., 2015, 11(10), pp 2709-2712.
[4] P.C.Thedoropoulos, et al, Nat. Chem. Biol., 2016, 12(4), pp 218-225.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not  a dangerous goods



NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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