(4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Amino benzophenone alkyne
Non-Fluorochemicals, Probe Building Blocks
KUMI0F05
2140866-77-7
 
129316437

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone
C17H15NO2
265.31
≥95.0%(HPLC)
Solid
>400ºC
250mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
(4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and amine synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its amine linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [1]
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. [2]
References:
[1] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
[2] H. Xu, E.C. Hett, A. Gopalsmy, M.D. Parikh, K.F. Geoghegan, R.E. Kyne, C.A. Menard, A. Narayanan, R.P. Robinson, D.S. Johnson, M.A. Tones, L.H. Jones, Mol. Biosyst., 2015, 11(10), pp 2709-2712.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not  a dangerous goods



NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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