4-bromoisobenzofuran-1(3H)-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-bromo-phthalide, 4-bromophthalide
Non-Fluorochemicals
KUMI0F44
102308-43-0
MFCD06412577
11593715
125363
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-bromoisobenzofuran-1(3H)-one
C8H5BrO2
213.03
≥97.0%
Solid
102-103°C
1g,5g,10g,20g,50g,100g and 500g
Store at room temperature
4-bromoisobenzofuran-1(3H)-one is a useful building block for various syntheses of biologically active compounds, e.g. n-butylphthalide derivatives, citalopram(C505000) analogs, etc..
Synthesis and biological activity of n-butylphthalide derivatives. [1]
Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5- carbonitrile) analogues at monoamine transporters. [2]
Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides. [3]
References:
[1] W.Wang, et al, Eur. J. Med. Chem., 2010, 45(5), pp 1941-1946.
[2] P.Zhang, et al, J. Med. Chem., 2010, 53(16), pp 6112-6121.
[3] T.Xia, et al, Org. Lett., 2017, 19(10), pp 2610-2613.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P280
29322090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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