Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Hydroxyl benzophenone alkyne
Non-Fluorochemicals, Probe Building Blocks


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Melting Point
White to Faint Brown Solid

250mg,500mg,1g,5g,10g and 50g
Store at -20°C Temperature
(4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is a trifunctional building block for chemical probe synthesis, typically employed for photoaffinity labeling in chemcial biology and medicinal chemistry. It contains a light-activated benzophenone (photoreactive group), terminal alkyne tag (clickable handle), and hydroxyl synthetic handle (connectivity group). When appended to a ligand or pharmacophore through its hydroxyl linker, this probe building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag.
Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. [1]
γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin. [2]
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. [3]
Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids. [4]
Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators. [5]
[1] D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20(21), pp 6237-6247.
[2] N.Pozdnyakov, et al, J. Biol. Chem., 2013, 288(14), pp 9710-9720.
[3] H. Xu, et al, Mol. Biosyst., 2015, 11(10), pp 2709-2712.
[4] B. Lee, et al, Bioorg. Med. Chem., 2016, 26(17), pp 4277-4281.
[5] K.J.Gregory, et al, ACS Chem. Biol., 2016, 11(1), pp 1870-1879.
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Not  a dangerous goods

NONH for all modes of transport

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