4-(methylamino)butanoate t-butyl ester is a pharmaceutically useful building block. Its typical applications include: preparation for a selective, potent, time-dependent HLE (Human leukocyte elastase) inhibitor suitable for formulation as a topical aerosol drug for possible clinical use, development of an orally active CCR5 antagonist based on antagonist, derivatives of tertiary amine benzocycloheptene and solution-phase synthesis of tetraproline peptide,which is a feasible alternative to the solid-phase synthesis of oligoproline CSPs.
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.
Synthesis of 1-benzothiepine and 1-benzazepine derivatives as orally active CCR5 antagonists.
Solution-phase synthesis and evaluation of tetraproline chiral stationary phases.