Ethyl 3-oxocyclobutane-1-carboxylate is a useful building block for the synthesis of various pharmaceutical compounds, e.g. cyclobutyl carboxylic acid derivatives and isoxazoline derivatives as antiparasitic agents, etc..
Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: Mechanism and scope.
Lactonization reactions through hydrolase-catalyzed peracid formation.Use of lipases for chemoenzymatic Baeyer-Villiger oxidations of cyclobutanones.
 X.Sun, et al, Tetrahedron Lett., 2014, 55(4), pp 842-844.
 D.Gonzalez-martinez, et al, J. Mol. Catal. B. Enzym., 2015, 114, pp 31-36.