Tert-butyl 3-oxoazetidine-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Boc-3-azetidinone,3-Oxoazetidine-1-carboxylic Acid tert-Butyl Ester
Non-Fluorochemicals
KUMI0F48
398489-26-4
MFCD01861741
1519404
11135637
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tert-butyl 3-oxoazetidine-1-carboxylate
C8H13NO3
171.20
≥98%(GC)
White to Yellow Solid
47-51°C
5g,10g,20g,50g,100g and 500g
Store at room temperature
Tert-butyl 3-oxoazetidine-1-carboxylate is a useful building block for the synthesis of various pharmaceutical compounds, e.g. Antibacterial aminoglycoside analogs and Azetidinyl diamides as monoacylglycerol lipase inhibitors, etc..
The synthesis of 3-aryl-3-azetidinyl acetic acid esters by rhodium(I)-catalysed conjugate addition of organoboron reagents. [1]
Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate. [2]
Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry. [3]
Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery. [4]
Synthesis of enantiopure dehydropiperidinones from α-amino acids and alkynes via azetidin-3-ones. [5]
An efficient synthesis of baricitinib. [6]
References:
[1] P.N.Collier, Tetrahedron Lett., 2009, 50(27), pp 3909-3911.
[2] M.J.Meyers, et al, Org. Lett., 2009, 11(16), pp 3523-3525.
[3] J.A.Burkhard, et al, Org. Lett., 2010, 12(9), pp 1944-1947.
[4] D.B.Li, et al, Org. Lett., 2011, 13(22), pp 6134-6136.
[5] N.Ishida, et al, Org. Lett., 2012, 14(15), pp 3898-3901.
[6] J.Xu, et al, J. Chem. Res., 2016, 40(4), pp 205-208.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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