Tert-butyl N-(3-oxocyclobutyl)carbamate is a useful building block for the synthesis of various pharmaceutical compounds, e.g. 5-HT1-like receptor agonists and highly potent HCV NS4B inhibitors, etc..
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: Mechanism and scope.
Highly Potent HCV NS4B Inhibitors with Activity against Multiple Genotypes. 
 T.M.Bridges, et al, Drug Metab. Dispos, 2013, 41(9), pp 1703-1714.
 X.Sun, et al, Tetrahedron Lett., 2014, 55(4), pp 842-844.
 B.Phillips, et al, J. Med. Chem., 2014, 57(5), pp 2161-216.