Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
TBTA
Non-Fluorochemicals, Heterocyclic Building Blocks, Non-Fluorinated Ligands
KUMI0F40
510758-28-8
MFCD09265124
24884865
9816134
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine
C30H30N10
530.63
≥97.0%(NMR,HPLC,LCMS)
White to Slightly pale reddish yellow Solid
132-143°C
100mg,200mg,500mg,1g,5g,10g,25g and 50g
Upon receipt store at -4°C
Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) is  a water-insoluble tris(triazolyl)amine ligand and must be first dissolved in DMSO or DMF. It is able to be introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction in order to mitigate thermodynamic instability of Cu(I) in aerobic media.
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition. [1]
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis. [2]
Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry. [3]
Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. [4]
Interspecies nutrient extraction and toxin delivery between bacteria. [5]
Silver nanoparticle plasmonic enhanced förster resonance energy transfer (FRET) imaging of protein-specific sialylation on the cell surface. [6]
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis. [7]
Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease. [8]
References:
[1]  Q.Wang, T.R.Chan, R.Hilgraf, V.V.Fokin, K.B.Sharpless, M.G.Finn, J. Am. Chem. Soc., 2003, 125(11), pp 3192-3913.
[2] T.R.Chan, R.Hilgraf, K.B.Sharpless, V.V.Fokin, Org. Lett., 2004, 6(17), pp 2853-2855.
[3] V.Hong, N.F.Steinmetz, M.Manchester, M.G.Finn, Bioconjugate Chem., 2010, 21(10), pp 1912-1916.
[4] M.Junker, T.A.Rapoport, Traffic, 2015, 16(12), pp 1306-1317.
[5] O.Stempler, A.K.Baidya, S.Bhattacharya, G.B.Malli Mohan, E.Tzipilevich, L.Sinai, G.Mamou, S. Benyehuda, Natural Commun. 8, 2017, 315.
[6] T.Zhao, T.Li, Y.Liu, Nanoscale, 2017, 9(28), pp 9841-9847.
[7] T.Salomón, C.Sibbersen, J.Hansen, D.Britz, M.V.Svart, T.S.Voss, N.Møller, N.Gregersen, K.A.Jørgensen, J.Palmfeldt, T.B.Poulsen, M. Johannsen, Cell Chem. Biol., 2017, 24(8), pp 935-943.
[8] S.Wang, F.Yang, V.A.Petyuk, M.E.Monroe, M.A.Gritsenko, K.D.Rodland, R.D.Smith, W.J.Qian, C.X.Gong, T.Liu, J. Pathol., 2017, 243(1), pp 78-88.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods
H413
P273,P501
2933.99.7900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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