Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is a water-soluble, very effective accelerating ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA is able to minimize perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering CuI loading in the catalyst formulation. Water-soluble THPTA click ligand further simplifies Click Chemistry by allowing the entire reaction to be run in water, affording biological compatibility for Click reactions.
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis.
Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry. 
Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. 
Interspecies nutrient extraction and toxin delivery between bacteria. 
Silver nanoparticle plasmonic enhanced förster resonance energy transfer (FRET) imaging of protein-specific sialylation on the cell surface. 
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis. 
Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.