1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-[2-(2,2-dimethylpropylamino)-1,1-dimethylethyl]-1H-imidazol-4-ylamine
Non-Fluorochemicals, AP I& Intermediates
KUMI0F995
865774-26-1

PubChem ID

Reax
 

PubChem ID
67163806
14456420
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-amine
C12H24N4
224.35
≥98%
White to Off-white Solid

10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-amine is an intermediate primarily used in the preparation of Nirogacestat (PF-03084014), a selective gamma-secretase inhibitor for the treatment of desmoid tumors that cannot be removed by surgery.
Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. [1]
Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. [2]
Safety and efficacy of gamma-secretase inhibitor nirogacestat (PF-03084014) in desmoid tumor: Report of four pediatric/young adult cases. [3]
References:
[1] P.Wei, et al, Mol. Cancer Ther., 2010, 9(6), pp 1618-1628.
[2] C.C.Zhang, et al, Clin. Cancer Res., 2012, 18(18), pp 5008-5019.
[3] T.Takahashi, et al, Pediatr. Blood Cancer, 2020, 67(10):e28636.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P305+P352,P305+P351+P338
29349990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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