1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-amine is an intermediate primarily used in the preparation of Nirogacestat (PF-03084014), a selective gamma-secretase inhibitor for the treatment of desmoid tumors that cannot be removed by surgery.
Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. 
Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. 
Safety and efficacy of gamma-secretase inhibitor nirogacestat (PF-03084014) in desmoid tumor: Report of four pediatric/young adult cases. 
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 C.C.Zhang, et al, Clin. Cancer Res., 2012, 18(18), pp 5008-5019.
 T.Takahashi, et al, Pediatr. Blood Cancer, 2020, 67(10):e28636.
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