1,4,8,11-Tetraazacyclotetradecane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Cyclam
Non-Fluorochemicals, API & Intermediates
KUMI0F992
295-37-4

PubChem ID

Reax
MFCD00005105

PubChem ID
64964
111811
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1,4,8,11-Tetraazacyclotetradecane
C10H24N4
200.33
≥98%
White to Light yellow Solid
184-186°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
1,4,8,11-Tetraazacyclotetradecane (also known as Cyclam) is an azamacrocycle typically used to form more stable metal complexes as compared to open chain ligands. It is also employed as key intermediate for the preparation of Plerixafor (AMD3100), an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream.
Cyclam (1,4,8,11-tetraazacyclotetradecane) with one methylphosphonate pendant arm: a new ligand for selective copper (II) binding. [1]
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties. [2]
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc (II) fenamates. [3]
References:
[1] S. Fuzerova, et al, Dalton Trans., 2005, 17, pp 2908-2915.
[2] I. Kalatskaya, et al, Mol. Pharmacol., 2009, 75(5), pp 1240-1247.
[3] R. Smolkova, et al, Polyhedron, 2018, 141, pp 230-238.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29339980
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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