1-Benzylpiperazine Hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Benzylpiperazine hydrochloride
Non-Fluorochemicals, API & Intermediates
KUMI0F990
110475-31-5

PubChem ID

Reax
MFCD04116529

PubChem ID
2756653
713234
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-Benzylpiperazine Hydrochloride
C11H17ClN2
212.72
≥98%
White to Light Yellow Solid
166-169°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
1-Benzylpiperazine Hydrochloride (also known as N-Benzylpiperazine hydrochloride) is a heterocyclic compound typically used as an intermediate in the preparation of Olaparib (AZD-2281, KU-59436) ,a small molecule inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities.
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A novel bioavailable inhibitor of Poly(ADP-ribose) polymerase-1. [1]
Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. [2]
Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry. [3]
References:
[1] K.A.Menear, et al, J. Med. Chem., 2008, 51(20), pp 6581-6591.
[2] N.Okamura, et al, J. Pharmacol. Exp. Ther., 2008, 325(3), pp 893-901.
[3] D.Davar, et al, Curr. Med. Chem., 2012, 19(23), pp 3907-3921.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated


29335990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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