1-Benzylpiperazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-benzylpiperazine
Non-Fluorochemicals, API & Intermediates
KUMI0F989
2759-28-6

PubChem ID

Reax
MFCD00005967

PubChem ID
141624
75994
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
1-Benzylpiperazine
C11H16N2
176.26
≥98%
Colorless to Light Yellow Liquid
131-134°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
1-Benzylpiperazine (also known as N-benzylpiperazine) is a heterocyclic compound typically used as a RSM in the preparation of Olaparib (AZD-2281, KU-59436) ,a small molecule inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities.
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A novel bioavailable inhibitor of Poly(ADP-ribose) polymerase-1. [1]
Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry. [2]
References:
[1] K.A.Menear, et al, J. Med. Chem., 2008, 51(20), pp 6581-6591.
[2] D.Davar, et al, Curr. Med. Chem., 2012, 19(23), pp 3907-3921.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+P338,P310
29335990
UN 3267 8/PG II

1. Product Specification
2. Safety Data Sheet
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