1-Chloro-7-methoxyisoquinoline-6-carbonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Chloranyl-7-methoxy-isoquinoline-6-carbonitrile
Nonfluorochemicals, API&Intermediates
KUMI0F300
1427393-40-5
MFCD23703810

Rea
97301664

Reax

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-Chloro-7-methoxyisoquinoline-6-carbonitrile
C11H7ClN2O
218.64
98%
White to Yellow Solid

5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
1-Chloro-7-methoxyisoquinoline-6-carbonitrile is a useful intermediate that typcially used in the preparation of PF06650833 as an inhibitor of Interleukin-1 receptor associated kinase 4(IRAK4) in the treatment of Waldenstrom macroglobulinemia, rheumatoid arthritis, lupus, and lymphomas.
Future therapeutic options for patients with Waldenström macroglobulinemia. [1]
Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). [2]
Kinase inhibitors in clinical practice: An expanding world. [3]
References:
[1] J.J.Castillo, et al, Best Pract. Res. Clin. Haematol., 2016, 29(2), pp 206-215.
[2] W.M.Seganish, Expert Opin. Ther. Pat., 2016, 26(8), pp 917-932.
[3] R.Pandey, et al, J. Allergy Clin. Immunol., 2018, 141(2), pp 522-524.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H318
P280,P301+PP310,P305+P351+P338
2933499090
UN 2811 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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