1-(Cyclopropylmethyl)piperazine diHydrochloride is a heterocycle intermediate typically used in the preparation of Mitapivat (AG-348), an activator of a pyruvate kinase PKM2 for the treatment of Pyruvate Kinase (PK) Deficiency.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. 
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. 
 C.Kung, et al, Blood, 2017, 130(11), pp 1347-1356.
 M.A.E.Rab, et al, Haematologica, 2020, DOI: 10.3324/haematol.2019.238865.
NONH for all modes of transport
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