1-(Cyclopropylmethyl)piperazine diHydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Cyclopropylmethylpiperazine 2HCl
Non-Fluorochemicals, API & Intermediates
KUMI0F993
373608-42-5

PubChem ID

Reax
MFCD08544420

PubChem ID
18403316

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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(Cyclopropylmethyl)piperazine diHydrochloride
C8H18Cl2N2
213.15
≥98%
White to Yellow Solid

5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
1-(Cyclopropylmethyl)piperazine diHydrochloride is a heterocycle intermediate typically used in the preparation of Mitapivat (AG-348), an activator of a pyruvate kinase PKM2 for the treatment of  Pyruvate Kinase (PK) Deficiency.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. [1]
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. [2]
References:
[1] C.Kung, et al, Blood, 2017, 130(11), pp 1347-1356.
[2] M.A.E.Rab, et al, Haematologica, 2020, DOI: 10.3324/haematol.2019.238865.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29335995
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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