1-(tert-Butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Anilino-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid
Nonfluorochemicals, API&Intermediates
KUMI0F248
1159835-31-0
MFCD12912781
45791677
19365583
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(tert-Butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid
C17H24N2O4
320.39
≥98%
White to Yellow Solid
153-155°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
1-(tert-Butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid (also known as Ph-NH-Pip(Boc)-OH) is an aromatic amine intermediate typically used in the prepartion of Sufentanil citrate, which is a opioid analgesic for use in anesthesia.
Sufentanil citrate: a new opioid analgesic for use in anesthesia. [1]
Aromatic amines as nucleophiles in the Bargellini reaction. [2]
Influence of intensive care treatment on the protein binding of sufentanil and hydromorphone during pain therapy in postoperative cardiac surgery patients. [3]
References:
[1] C.E.Rosow, Pharmacotherapy, 1984, 4(1), pp 11-9.
[2] K.J.Butcher, et al, Tetrahedron Lett., 2009, 21(50), pp 2497-2500.
[3] T.I.Saari, et al, Br. J. Anaesth., 2014, 113(4), pp 677-687.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P280,P305+P351+P338
2933399090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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