1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-(Oxan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Nonfluorochemicals, API&Intermediates
KUMI0F276
903550-26-5
MFCD09037501

Rea
21866310

Reax
10351732
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester
C14H23BN2O3
278.16
98%
White to Orange Solid
74-78°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a heterocyclic building block that typically used in the preparation of ABL001 as a potent and selective allosteric BCR-ABL1 inhibitor for the treatment of Chronic myelogenous leukemia (CML).
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. [1]
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. [2]
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects. [3]
References:
[1] A.A.Wylie, et al, Nature, 2017, 543(7647), pp 733-737.
[2] J.Schoepfer, et al, J. Med. Chem., 2018, 61(18), pp 8120-8135.
[3] P.Tran, et al, Xenobiotica, 2019, 1594449, doi: 10.1080/00498254.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture


2934999090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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